2. Gene
  3. CHFR - checkpoint with forkhead and ring finger domains Gene

CHFR - checkpoint with forkhead and ring finger domains Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RNF116; RNF196

Gene ID: 55743 | Gene type: protein coding

About CHFR

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,832,356-132,887,618 (from NCBI)

This gene has 24 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

CHFR Products(5)

mRNA Protein Name
NM_001161344.1 NP_001154816.1 E3 ubiquitin-protein ligase CHFR isoform 1
NM_001161345.1 NP_001154817.1 E3 ubiquitin-protein ligase CHFR isoform 2
NM_001161346.2 NP_001154818.1 E3 ubiquitin-protein ligase CHFR isoform 3
NM_001161347.1 NP_001154819.1 E3 ubiquitin-protein ligase CHFR isoform 5
NM_018223.2 NP_060693.2 E3 ubiquitin-protein ligase CHFR isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nucleotide binding IDA
IDA: Inferred from direct assay
18172500 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15467728 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18172500 GOA
Biological Process GO Annotation Evidence Reference Source
involved in meiotic spindle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
10935642 GOA
involved in mitotic G2/M transition checkpoint IMP
IMP: Inferred from mutant phenotype
18172500 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19182791 GOA
Cellular Component GO Annotation Evidence Reference Source
located in PML body IDA
IDA: Inferred from direct assay
15467728 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18172500 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHFR Protein Structure

FHA

FHA: FHA domain (38 - 105)

zf-RING_2

zf-RING_2: Ring finger domain (303 - 343)

  • 0
  • 200
  • 400
  • 600
  • 664 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CHFR

RING finger protein 196

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02623 CHFR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHFR RGD RGD:1306360
Bos taurus CHFR VGNC VGNC:27288
Macaca mulatta CHFR VGNC VGNC:71064
Felis catus CHFR VGNC VGNC:60853
Canis familiaris CHFR VGNC VGNC:39211
Mus musculus CHFR MGD MGI:2444898
Others CHFR NCBI