Bace2 - beta-site APP-cleaving enzyme 2 Gene

Mus musculus

Also known as ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 1110059C24Rik

Gene ID: 56175 | Gene type: protein coding

About Bace2

Chromosome 16: 97,157,942-97,244,136 forward strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 215 orthologues, 8 paralogues and is associated with 10 phenotypes. Biased expression in stomach adult (RPKM 52.5), colon adult (RPKM 18.7) and 8 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase Enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased Insulin secretion. [provided by RefSeq, Jul 2016]

Bace2 Products(1)

mRNA	Protein	Name
NM_019517.5	NP_062390.3	beta-secretase 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IGI IGI: Inferred from genetic interaction	31838721	MGI
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	31838721	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in melanosome organization	IMP IMP: Inferred from mutant phenotype	23754390	MGI
involved in signaling receptor ligand precursor processing	IGI IGI: Inferred from genetic interaction	31838721	MGI
involved in signaling receptor ligand precursor processing	IMP IMP: Inferred from mutant phenotype	31838721	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21907142	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace2 Protein Structure

beta_secretase_like

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

beta-secretase 2

aspartyl protease 1	beta-site amyloid precursor protein cleaving enzyme 2
memapsin-1	membrane-associated aspartic protease 1
theta-secretase

Recombinant Bace2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75588	BACE2 Protein, Mouse (HEK293, His)	Q9JL18 (A20-P462)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16759	Verubecestat	Inhibitor	99.56%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136742	BACE2-IN-1	Inhibitor	99.4%	Unkown
HY-161359	BACE1-IN-14	Inhibitor	/	Unkown
HY-12938	AMG-8718	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bace2	NCBI	NCBI:25825

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