2. Gene
  3. PSG6 - pregnancy specific beta-1-glycoprotein 6 Gene

PSG6 - pregnancy specific beta-1-glycoprotein 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12

Gene ID: 5675 | Gene type: protein coding

About PSG6

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:42,902,086-42,917,894 (from NCBI)

This gene has 9 transcripts (splice variants), 628 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 62.8).

Summary

This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

PSG6 Products(2)

mRNA Protein Name
NM_001031850.4 NP_001027020.1 pregnancy-specific beta-1-glycoprotein 6 isoform b precursor
NM_002782.5 NP_002773.1 pregnancy-specific beta-1-glycoprotein 6 isoform a precursor

PSG6 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (40 - 126)

Ig_2

Ig_2: Immunoglobulin domain (148 - 233)

Ig_2

Ig_2: Immunoglobulin domain (254 - 327)

Ig_2

Ig_2: Immunoglobulin domain (334 - 412)

  • 0
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  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

pregnancy-specific beta-1-glycoprotein 6

PS-beta-G-10

Recombinant PSG6 Proteins

Cat. No. Product Name Accession Purity
HY-P77161 PSG6 Protein, Human (sf9, His) Q00889-2/NP_001027020 (Q35-H424) ≥95%

Related Diseases

Diseases Alias
Chorioangioma

Placental Hemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11285 PSG6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown