TWSG1 - twisted gastrulation BMP signaling modulator 1 Gene

Homo sapiens

Also known as TSG

Gene ID: 57045 | Gene type: protein coding

About TWSG1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,334,773-9,402,420 (from NCBI)

This gene has 3 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in endometrium (RPKM 35.8), gall bladder (RPKM 26.4) and 24 other tissues.

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; and transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TWSG1 Products(1)

mRNA	Protein	Name
NM_020648.6	NP_065699.1	twisted gastrulation protein homolog 1 precursor

TWSG1 Protein Structure

Tsg

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

twisted gastrulation protein homolog 1

twisted gastrulation homolog 1

Recombinant TWSG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71391	TWSG1 Protein, Human (HEK293, His)	Q9GZX9-1 (C26-F223)	≥95%

Related Diseases

Diseases

Alias

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Prolapse Of Urethra

Urethrocele

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15284	TWSG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TWSG1	VGNC	VGNC:48004
Mus musculus	TWSG1	MGD	MGI:2137520
Felis catus	TWSG1	VGNC	VGNC:66718
Bos taurus	TWSG1	VGNC	VGNC:36528
Macaca mulatta	TWSG1	VGNC	VGNC:104255
Rattus norvegicus	TWSG1	RGD	RGD:1311215
Others	TWSG1	NCBI

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