TWSG1 - twisted gastrulation BMP signaling modulator 1 Gene

Homo sapiens

Also known as TSG

Gene ID: 57045 | Gene type: protein coding

About TWSG1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,334,773-9,402,420 (from NCBI)

This gene has 3 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in endometrium (RPKM 35.8), gall bladder (RPKM 26.4) and 24 other tissues.

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; and transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TWSG1 Products(1)

mRNA	Protein	Name
NM_020648.6	NP_065699.1	twisted gastrulation protein homolog 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	17164348	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of CD4-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	17164348	GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	17164348	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	17164348	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	17164348	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	17164348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TWSG1 Protein Structure

Tsg

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

twisted gastrulation protein homolog 1

twisted gastrulation homolog 1

TWSG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TWSG1	Q9GZX9	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TWSG1	Q9GZX9	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TWSG1	Q9GZX9	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	TWSG1	Q9GZX9	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	TWSG1	Q9GZX9	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	TWSG1	Q9GZX9	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	TWSG1	Q9GZX9	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	TWSG1	Q9GZX9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TWSG1	Q9GZX9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TWSG1	Q9GZX9	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	TWSG1	Q9GZX9	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	TWSG1	Q9GZX9	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	TWSG1	Q9GZX9	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TWSG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71391	TWSG1 Protein, Human (HEK293, His)	Q9GZX9-1 (C26-F223)	≥95%

Related Diseases

Diseases

Alias

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Prolapse Of Urethra

Urethrocele

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15284	TWSG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TWSG1	VGNC	VGNC:48004
Mus musculus	TWSG1	MGD	MGI:2137520
Felis catus	TWSG1	VGNC	VGNC:66718
Bos taurus	TWSG1	VGNC	VGNC:36528
Macaca mulatta	TWSG1	VGNC	VGNC:104255
Rattus norvegicus	TWSG1	RGD	RGD:1311215
Others	TWSG1	NCBI

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