Uts2r - urotensin 2 receptor Gene

Rattus norvegicus

Also known as Senr; Gpr14; UR-2-R

Gene ID: 57305 | Gene type: protein coding

About Uts2r

Primary_assembly 10: 106,438,092-106,439,252 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 54 orthologues, 24 paralogues and is associated with 9 phenotypes.

Summary

Enables urotensin II receptor activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of circadian sleep/wake cycle, wakefulness; and regulation of blood pressure. Located in early endosome; plasma membrane; and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Uts2r Products(1)

mRNA	Protein	Name
NM_020537.1	NP_065412.1	urotensin-2 receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables urotensin II receptor activity	IDA IDA: Inferred from direct assay	16141412	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16531985	RGD
involved in negative regulation of glomerular filtration	IMP IMP: Inferred from mutant phenotype	16531985	RGD
involved in negative regulation of urine volume	IMP IMP: Inferred from mutant phenotype	16531985	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17089015	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17900760	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15549273	RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep	IMP IMP: Inferred from mutant phenotype	15944374	RGD
involved in positive regulation of circadian sleep/wake cycle, wakefulness	IMP IMP: Inferred from mutant phenotype	15944374	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15549273	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	16919371	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15554454	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17184580	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	16141412	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	16141412	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Uts2r Protein Structure

7tmA_UII-R

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

urotensin-2 receptor

G-protein coupled receptor 14	G-protein coupled sensory epithelial neuropeptide-like receptor
UR-II-R	putative G protein-coupled receptor (SENR)
urotensin II receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15584	UTS2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15585	Uts2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15586	Uts2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Uts2r	NCBI	NCBI:2837

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