CASKIN2 - CASK interacting protein 2 Gene

Homo sapiens

Also known as ANKS5B

Gene ID: 57513 | Gene type: protein coding

About CASKIN2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,500,261-75,515,537 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 13.1), lung (RPKM 12.8) and 24 other tissues.

Summary

This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

CASKIN2 Products(2)

mRNA	Protein	Name
NM_001142643.3	NP_001136115.1	caskin-2 isoform b
NM_020753.5	NP_065804.2	caskin-2 isoform a

CASKIN2 Protein Structure

Ank_2

Ank_4

Ank_2

SH3_2

SAM_1

0
200
400
600
800
1000
1202 a.a.

Protein Preferred Names

Protein Names

caskin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01940	CASKIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CASKIN2	RGD	RGD:1309738
Canis familiaris	CASKIN2	VGNC	VGNC:38731
Mus musculus	CASKIN2	MGD	MGI:2157062
Macaca mulatta	CASKIN2	VGNC	VGNC:70577
Felis catus	CASKIN2	VGNC	VGNC:60378
Bos taurus	CASKIN2	VGNC	VGNC:26778

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