1. Gene
  2. NLGN2 - neuroligin 2 Gene

NLGN2 - neuroligin 2 Gene

Homo sapiens
Gene ID: 57555 | Gene type: protein coding

About NLGN2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,404,653-7,419,860 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 237 orthologues and 13 paralogues. Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN2 Products(1)

mRNA Protein Name
NM_020795.4 NP_065846.1 neuroligin-2 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22528485 GOA
acts upstream of or within positive regulation of protein localization to synapse IDA
IDA: Inferred from direct assay
24613359 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLGN2 Protein Structure

COesterase

COesterase: Carboxylesterase family (40 - 601)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

neuroligin-2

Related Diseases

Diseases Alias
Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome

CDFES

PTHSL1

Cdfe Syndrome

Pitt-Hopkins Like Syndrome 1

Pitt-Hopkins-Like Syndrome-1

Cntnap2-Related Developmental And Epileptic Encephalopathy

Cntnap2-Related Dee

Mesh

D006985

Mesh

D008607

Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders

Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus NLGN2 MGD MGI:2681835
Felis catus NLGN2 VGNC VGNC:63822
Canis familiaris NLGN2 VGNC VGNC:43839
Bos taurus NLGN2 VGNC VGNC:55861
Macaca mulatta NLGN2 VGNC VGNC:104635
Rattus norvegicus NLGN2 RGD RGD:621118