NLGN2 - neuroligin 2 Gene

Homo sapiens

Gene ID: 57555 | Gene type: protein coding

About NLGN2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,404,653-7,419,860 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 237 orthologues and 13 paralogues. Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN2 Products(1)

mRNA	Protein	Name
NM_020795.4	NP_065846.1	neuroligin-2 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	22528485	GOA
acts upstream of or within positive regulation of protein localization to synapse	IDA IDA: Inferred from direct assay	24613359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLGN2 Protein Structure

COesterase

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

neuroligin-2

Related Diseases

Diseases

Alias

Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome	CDFES
PTHSL1	Cdfe Syndrome
Pitt-Hopkins Like Syndrome 1	Pitt-Hopkins-Like Syndrome-1
Cntnap2-Related Developmental And Epileptic Encephalopathy	Cntnap2-Related Dee
Mesh	D006985
Mesh	D008607

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09340	NLGN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NLGN2	MGD	MGI:2681835
Felis catus	NLGN2	VGNC	VGNC:63822
Canis familiaris	NLGN2	VGNC	VGNC:43839
Bos taurus	NLGN2	VGNC	VGNC:55861
Macaca mulatta	NLGN2	VGNC	VGNC:104635
Rattus norvegicus	NLGN2	RGD	RGD:621118

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