USP35 - ubiquitin specific peptidase 35 Gene

Homo sapiens

Gene ID: 57558 | Gene type: protein coding

About USP35

This gene has 7 transcripts (splice variants), 131 orthologues and 71 paralogues. Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating Enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a MicroRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

USP35 Products(1)

mRNA	Protein	Name
NM_020798.4	NP_065849.1	ubiquitin carboxyl-terminal hydrolase 35

USP35 Protein Structure

UCH

0
200
400
600
800
1018 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 35

deubiquitinating enzyme 35

Related Diseases

Diseases

Alias

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15546	USP35 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP35	VGNC	VGNC:36725
Rattus norvegicus	USP35	RGD	RGD:1565984
Canis familiaris	USP35	VGNC	VGNC:48191
Felis catus	USP35	VGNC	VGNC:66881
Macaca mulatta	USP35	VGNC	VGNC:79218
Mus musculus	USP35	MGD	MGI:2685339

Name
Email *

	Sorry, but the email address you supplied was invalid.