EBF4 - EBF family member 4 Gene

Homo sapiens

Also known as COE4; OE-4; O/E-4

Gene ID: 57593 | Gene type: protein coding

About EBF4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,692,780-2,760,108 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in prostate (RPKM 9.6), endometrium (RPKM 8.9) and 24 other tissues.

Summary

EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

EBF4 Products(3)

mRNA	Protein	Name
NM_001110514.1	NP_001103984.1	transcription factor COE4 isoform 1
NM_001395167.1	NP_001382096.1	transcription factor COE4 isoform 2
NM_001395168.1	NP_001382097.1	transcription factor COE4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	35939714	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	35939714	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	35939714	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	35939714	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	35939714	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	35939714	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	35939714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF4 Protein Structure

TIG

0
100
200
300
400
500
602 a.a.

Protein Preferred Names

Protein Names

transcription factor COE4

early B cell factor 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04127	EBF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EBF4	VGNC	VGNC:40177
Rattus norvegicus	EBF4	RGD	RGD:1588215
Felis catus	EBF4	VGNC	VGNC:80090
Macaca mulatta	EBF4	VGNC	VGNC:71932
Mus musculus	EBF4	MGD	MGI:2385972
Bos taurus	EBF4	VGNC	VGNC:28298

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