HES4 - hes family bHLH transcription factor 4 Gene

Homo sapiens

Also known as bHLHb42

Gene ID: 57801 | Gene type: protein coding

About HES4

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:998,964-1,000,097 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 12 paralogues. Broad expression in fat (RPKM 3.0), prostate (RPKM 2.2) and 19 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HES4 Products(3)

mRNA	Protein	Name
NM_001142467.2	NP_001135939.1	transcription factor HES-4 isoform 1
NM_001410700.1	NP_001397629.1	transcription factor HES-4 isoform 3
NM_021170.4	NP_066993.1	transcription factor HES-4 isoform 2

HES4 Protein Structure

HLH

Hairy_orange

0
100
200
221 a.a.

Protein Preferred Names

Protein Names

transcription factor HES-4

bHLH factor Hes4

Related Diseases

Diseases

Alias

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06137	HES4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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