SLC46A2 - solute carrier family 46 member 2 Gene

Homo sapiens

Also known as Ly110; TSCOT

Gene ID: 57864 | Gene type: protein coding

About SLC46A2

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:112,878,920-112,890,876 (from NCBI)

This gene has 2 transcripts (splice variants), 227 orthologues and 2 paralogues. Biased expression in lung (RPKM 9.2), skin (RPKM 5.1) and 6 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Involved in positive regulation of nucleotide-binding activity oligomerization domain containing 1 signaling pathway. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC46A2 Products(1)

mRNA	Protein	Name
NM_033051.4	NP_149040.3	thymic stromal cotransporter homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclic-GMP-AMP transmembrane transporter activity	IDA IDA: Inferred from direct assay	34235268	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cyclic-GMP-AMP transmembrane import across plasma membrane	IDA IDA: Inferred from direct assay	34235268	GOA
involved in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP IMP: Inferred from mutant phenotype	28539433	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	34235268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC46A2 Protein Structure

MFS_1

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

thymic stromal cotransporter homolog

thymic stromal co-transporter

Related Diseases

Diseases

Alias

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13261	SLC46A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC46A2	MGD	MGI:1353616
Felis catus	SLC46A2	VGNC	VGNC:65380
Rattus norvegicus	SLC46A2	RGD	RGD:1310485
Macaca mulatta	SLC46A2	VGNC	VGNC:77714
Canis familiaris	SLC46A2	VGNC	VGNC:46427
Bos taurus	SLC46A2	VGNC	VGNC:34885

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