CACTIN - cactin, spliceosome C complex subunit Gene

Homo sapiens

Also known as fSAPc; C19orf29; NY-REN-24

Gene ID: 58509 | Gene type: protein coding

About CACTIN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,610,645-3,626,790 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 5.5), testis (RPKM 4.7) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CACTIN Products(2)

mRNA	Protein	Name
NM_001080543.2	NP_001074012.1	cactin
NM_021231.2	NP_067054.1	cactin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20829348	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	20829348	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	20829348	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20829348	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	28062851	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	26363554	GOA
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	20829348	GOA
involved in negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20829348	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20829348	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20829348	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15302935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACTIN Protein Structure

Cactin_mid

CactinC_cactus

0
200
400
600
800
867 a.a.

Protein Preferred Names

Protein Names

cactin

NY REN 24 antigen

Related Diseases

Diseases

Alias

Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

Hypophosphatemic Nephrolithiasis/Osteoporosis 2	NPHLOP2
Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2	Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2

Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01816	CACTIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CACTIN	RGD	RGD:1563634
Bos taurus	CACTIN	VGNC	VGNC:58364
Felis catus	CACTIN	VGNC	VGNC:60313
Mus musculus	CACTIN	MGD	MGI:1917562
Canis familiaris	CACTIN	VGNC	VGNC:38653
Macaca mulatta	CACTIN	VGNC	VGNC:108486

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