RASGRF2 - Ras protein specific guanine nucleotide releasing factor 2 Gene

Homo sapiens

Also known as GRF2; RAS-GRF2

Gene ID: 5924 | Gene type: protein coding

About RASGRF2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,960,363-81,230,162 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 24 paralogues. Broad expression in brain (RPKM 9.6), ovary (RPKM 7.2) and 18 other tissues.

Summary

Ras GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both Ras and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

RASGRF2 Products(1)

mRNA	Protein	Name
NM_006909.3	NP_008840.1	ras-specific guanine nucleotide-releasing factor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	27856453	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	27856453	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRF2 Protein Structure

RhoGEF

RasGEF_N

RasGEF

0
200
400
600
800
1000
1237 a.a.

Protein Preferred Names

Protein Names

ras-specific guanine nucleotide-releasing factor 2

ras guanine nucleotide exchange factor 2

Related Diseases

Diseases

Alias

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11692	RASGRF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RASGRF2	VGNC	VGNC:45371
Rattus norvegicus	RASGRF2	RGD	RGD:69413
Macaca mulatta	RASGRF2	VGNC	VGNC:84486
Felis catus	RASGRF2	VGNC	VGNC:69250
Bos taurus	RASGRF2	VGNC	VGNC:33746
Mus musculus	RASGRF2	MGD	MGI:109137

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