HRH4 - histamine receptor H4 Gene

Homo sapiens

Also known as H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105

Gene ID: 59340 | Gene type: protein coding

About HRH4

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,460,637-24,479,974 (from NCBI)

This gene has 2 transcripts (splice variants), 105 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a Histamine Receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

HRH4 Products(3)

mRNA	Protein	Name
NM_021624.4	NP_067637.2	histamine H4 receptor isoform 1
NM_001160166.2	NP_001153638.1	histamine H4 receptor isoform 3
NM_001143828.2	NP_001137300.1	histamine H4 receptor isoform 2

HRH4 Protein Structure

7tm_1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

histamine H4 receptor

G-protein coupled receptor 105	SP9144
pfi-013

Related Diseases

Diseases

Alias

Chronic Conjunctivitis

Meniere Disease

Meniere'S Disease	Otogenic Vertigo
Ménière Disease	Ménière'S Disease
Mnire'S Vertigo	Auditory Vertigo
Aural Vertigo	Meniere'S Syndrome
Ménière'S Vertigo	Primary Endolymphatic Hydrops
Menieres Disease	Vertigo, Aural
Labyrinth Hydrops	Labyrinthine Hydrops
Labyrinthine Vertigo	Ménière Syndrome
Ménière Vertigo	Idiopathic Endolymphatic Hydrops

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Pericarditis

Allergic Conjunctivitis

Conjunctivitis Allergic	Conjunctivitis, Allergic
Allergen-Induced Conjunctivitis	Seasonal Allergic Conjunctivitis
Perennial Allergic Conjunctivitis	Spring Conjunctivitis
Acute Allergic Conjunctivitis

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Nasal Cavity Disease

Disorder Of Nasal Cavity

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06368	HRH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06369	Hrh4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06370	Hrh4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HRH4	VGNC	VGNC:41788
Macaca mulatta	HRH4	VGNC	VGNC:73404
Felis catus	HRH4	VGNC	VGNC:62841
Bos taurus	HRH4	VGNC	VGNC:29956
Mus musculus	HRH4	MGD	MGI:2429635
Rattus norvegicus	HRH4	RGD	RGD:620631

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