RPS4Y1 - ribosomal protein S4 Y-linked 1 Gene

Homo sapiens

Also known as S4; RPS4Y

Gene ID: 6192 | Gene type: protein coding

About RPS4Y1

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:2,841,602-2,867,268 (from NCBI)

This gene has 4 transcripts (splice variants), 56 orthologues and 2 paralogues. Broad expression in prostate (RPKM 119.8), small intestine (RPKM 81.8) and 20 other tissues.

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS4Y1 Products(1)

mRNA	Protein	Name
NM_001008.4	NP_000999.1	40S ribosomal protein S4, Y isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in translation	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ribosome	IDA IDA: Inferred from direct assay	8139551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS4Y1 Protein Structure

RS4NT

Ribosomal_S4e

KOW

0
100
200
263 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S4, Y isoform 1

40S ribosomal protein S4, Y

ribosomal protein S4, Y-linked

Related Diseases

Diseases

Alias

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12245	RPS4Y1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS4Y1	MGD	MGI:98158
Macaca mulatta	RPS4Y1	VGNC	VGNC:101431

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