ACSM3 - acyl-CoA synthetase medium chain family member 3 Gene

Homo sapiens

Also known as SA; SAH

Gene ID: 6296 | Gene type: protein coding

About ACSM3

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,674,405-20,797,581 (from NCBI)

This gene has 15 transcripts (splice variants), 155 orthologues and 13 paralogues. Broad expression in liver (RPKM 29.1), kidney (RPKM 21.9) and 17 other tissues.

Summary

Enables butyrate-CoA Ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Implicated in IgA glomerulonephritis. Biomarker of ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2022]

ACSM3 Products(2)

mRNA	Protein	Name
NM_005622.4	NP_005613.2	acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 1
NM_202000.3	NP_973729.1	acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 2

ACSM3 Protein Structure

AMP-binding

AMP-binding_C

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A synthetase ACSM3, mitochondrial

SA (rat hypertension-associated) homolog

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Speech Delay And Variable Ocular Anomalies

NEDSOA

Colitis

Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2

Spinal Muscular Atrophy, Jerash Type	DSMA2
Neuropathy, Distal Hereditary Motor, Jerash Type	Hmnj
Autosomal Recessive Distal Spinal Muscular Atrophy 2	Neuronopathy, Distal Hereditary Motor, Jerash Type
Distal Spinal Muscular Atrophy 2	Dhmnj
Hereditary Motor Neuropathy, Jerash Type	Motor Neuropathy, Distal, Jerash Type
Distal Hereditary Motor Neuropathy, Jerash Type	Distal Hereditary Motor Neuropathy Jerash Type
Spinal Muscular Atrophy Jerash Type	Mndj
Autosomal Recessive Distal Spinal Muscular Atrophy Type 2	Distal Spinal Muscular Atrophy, Autosomal Recessive, 2
Atrophy, Muscular, Spinal, Distal, Autosomal Recessive, Type 2

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Iminoglycinuria

Iminoglycinuria, Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00207	ACSM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACSM3	VGNC	VGNC:69376
Bos taurus	ACSM3	VGNC	VGNC:49960
Canis familiaris	ACSM3	VGNC	VGNC:54007
Mus musculus	ACSM3	MGD	MGI:99538
Rattus norvegicus	ACSM3	RGD	RGD:62086
Felis catus	ACSM3	VGNC	VGNC:59538

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