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  3. PDF - peptide deformylase, mitochondrial Gene

PDF - peptide deformylase, mitochondrial Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 64146 | Gene type: protein coding

About PDF

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,326,913-69,330,588 (from NCBI)

This gene has 1 transcript (splice variant) and 178 orthologues. Ubiquitous expression in kidney (RPKM 13.2), testis (RPKM 10.1) and 25 other tissues.

Summary

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent Peptides. In eubacteria, deformylation of nascent Peptides is required for subsequent cleavage of initiating methionines by methionine Aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of Cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq, Nov 2008]

PDF Products(1)

mRNA Protein Name
NM_022341.2 NP_071736.1 peptide deformylase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptide deformylase activity IDA
IDA: Inferred from direct assay
15489958 GOA
Biological Process GO Annotation Evidence Reference Source
involved in N-terminal protein amino acid modification IDA
IDA: Inferred from direct assay
15489958 GOA
involved in peptidyl-methionine modification IDA
IDA: Inferred from direct assay
15489958 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15489958 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
15489958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDF Protein Structure

Pep_deformylase

Pep_deformylase: Polypeptide deformylase (66 - 232)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

peptide deformylase, mitochondrial

peptide deformylase-like protein

Related Diseases

Diseases Alias
Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12480 Lanopepden Inhibitor 98.62% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113952 Actinonin 98.61% Unkown
HY-113753 PDF-IN-1 Inhibitor / Unkown
HY-119728 FR198248 Inhibitor / Unkown
HY-168853 Antibacterial agent 261 Inhibitor / Unkown
HY-P10400 AtPep1 / Unkown
HY-RS10249 PDF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-102008 LBM-415 Inhibitor / Unkown
HY-116598 Lanopepden mesylate Inhibitor / Unkown
HY-136885 (S,S)-TAPI-0 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDF MGD MGI:1915273
Bos taurus PDF VGNC VGNC:49562
Macaca mulatta PDF VGNC VGNC:104744
Rattus norvegicus PDF RGD RGD:1582894
Felis catus PDF VGNC VGNC:64081
Canis familiaris PDF VGNC VGNC:49608
Macaca fascicularis PDF NCBI
Others PDF NCBI