1. Gene
  2. WDR13 - WD repeat domain 13 Gene

WDR13 - WD repeat domain 13 Gene

Homo sapiens

Also known as MG21

Gene ID: 64743 | Gene type: protein coding

About WDR13

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,590,033-48,608,869 (from NCBI)

This gene has 12 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 22.5), kidney (RPKM 22.5) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum Insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]

WDR13 Products(4)

mRNA Protein Name
NM_001166426.3 NP_001159898.1 WD repeat-containing protein 13 isoform 2
NM_001347217.2 NP_001334146.1 WD repeat-containing protein 13 isoform 1
NM_001347219.2 NP_001334148.1 WD repeat-containing protein 13 isoform 2
NM_017883.6 NP_060353.2 WD repeat-containing protein 13 isoform 1

WDR13 Protein Structure

WD40

WD40: WD domain, G-beta repeat (208 - 244)

WD40

WD40: WD domain, G-beta repeat (447 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 13

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR13 VGNC VGNC:78957
Felis catus WDR13 VGNC VGNC:67016
Rattus norvegicus WDR13 RGD RGD:1560982
Canis familiaris WDR13 VGNC VGNC:48352
Mus musculus WDR13 MGD MGI:1914661
Bos taurus WDR13 VGNC VGNC:36883