ST6GAL1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Gene

Homo sapiens

Also known as ST6N; CDw75; SIAT1; ST6GalI

Gene ID: 6480 | Gene type: protein coding

About ST6GAL1

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,930,526-187,078,553 (from NCBI)

This gene has 24 transcripts (splice variants), 232 orthologues and 14 paralogues. Broad expression in liver (RPKM 87.7), lymph node (RPKM 37.8) and 18 other tissues.

Summary

This gene encodes a member of Glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

ST6GAL1 Products(4)

mRNA	Protein	Name
NM_001353916.2	NP_001340845.1	beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_003032.3	NP_003023.1	beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173216.2	NP_775323.1	beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173217.2	NP_775324.1	beta-galactoside alpha-2,6-sialyltransferase 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-galactoside alpha-2,6-sialyltransferase activity	IDA IDA: Inferred from direct assay	23999306	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16237761	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20378551	GOA
enables sialyltransferase activity	IDA IDA: Inferred from direct assay	21081508	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acetylneuraminate metabolic process	IDA IDA: Inferred from direct assay	23999306	GOA
involved in protein N-linked glycosylation via asparagine	IDA IDA: Inferred from direct assay	23999306	GOA
involved in sialylation	IDA IDA: Inferred from direct assay	23999306	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	20378551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST6GAL1 Protein Structure

Glyco_transf_29

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

beta-galactoside alpha-2,6-sialyltransferase 1

B-cell antigen CD75

Recombinant ST6GAL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71116	ST6GAL1 Protein, Human (HEK293, His)	P15907 (K27-C406)	≥95%

Related Diseases

Diseases

Alias

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Congenital Muscular Dystrophy-Dystroglycanopathy Type A11

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A11	Mddga11
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease B3galnt2-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A11

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13852	ST6GAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ST6GAL1	MGD	MGI:108470
Canis familiaris	ST6GAL1	VGNC	VGNC:46856
Felis catus	ST6GAL1	VGNC	VGNC:65726
Bos taurus	ST6GAL1	VGNC	VGNC:35337
Macaca mulatta	ST6GAL1	VGNC	VGNC:77823
Rattus norvegicus	ST6GAL1	RGD	RGD:3676
Others	ST6GAL1	NCBI

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