1. Gene
  2. ST6GAL1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Gene

ST6GAL1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Gene

Homo sapiens

Also known as ST6N; CDw75; SIAT1; ST6GalI

Gene ID: 6480 | Gene type: protein coding

About ST6GAL1

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,930,526-187,078,553 (from NCBI)

This gene has 24 transcripts (splice variants), 232 orthologues and 14 paralogues. Broad expression in liver (RPKM 87.7), lymph node (RPKM 37.8) and 18 other tissues.

Summary

This gene encodes a member of Glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

ST6GAL1 Products(4)

mRNA Protein Name
NM_001353916.2 NP_001340845.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_003032.3 NP_003023.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173216.2 NP_775323.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173217.2 NP_775324.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform b

ST6GAL1 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (156 - 388)

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  • 406 a.a.
Protein Preferred Names Protein Names

beta-galactoside alpha-2,6-sialyltransferase 1

B-cell antigen CD75

Recombinant ST6GAL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71116 ST6GAL1 Protein, Human (HEK293, His) P15907 (K27-C406) ≥95%

Related Diseases

Diseases Alias
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Congenital Muscular Dystrophy-Dystroglycanopathy Type A11

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A11

Mddga11

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease B3galnt2-Related

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A11

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus ST6GAL1 MGD MGI:108470
Canis familiaris ST6GAL1 VGNC VGNC:46856
Felis catus ST6GAL1 VGNC VGNC:65726
Bos taurus ST6GAL1 VGNC VGNC:35337
Macaca mulatta ST6GAL1 VGNC VGNC:77823
Rattus norvegicus ST6GAL1 RGD RGD:3676
Others ST6GAL1 NCBI