ST3GAL1 - ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Gene

Homo sapiens

Also known as ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1

Gene ID: 6482 | Gene type: protein coding

About ST3GAL1

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,454,848-133,571,887 (from NCBI)

This gene has 16 transcripts (splice variants), 437 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues.

Summary

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its Sialyltransferase activity. This protein, which is a member of Glycosyltransferase family 29, can use the same acceptor substrates as does Sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

ST3GAL1 Products(2)

mRNA	Protein	Name
NM_003033.4	NP_003024.1	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_173344.3	NP_775479.1	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

ST3GAL1 Protein Structure

Glyco_transf_29

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase

Related Diseases

Diseases

Alias

Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70298	ST3 β-Gal α-2,3-Sialyltransferase 1		/	Unkown
HY-RS13846	ST3GAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ST3GAL1	VGNC	VGNC:46850
Macaca mulatta	ST3GAL1	VGNC	VGNC:77825
Rattus norvegicus	ST3GAL1	RGD	RGD:1309373
Bos taurus	ST3GAL1	VGNC	VGNC:35331
Mus musculus	ST3GAL1	MGD	MGI:98304
Felis catus	ST3GAL1	VGNC	VGNC:65719

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