Sln - sarcolipin Gene

Mus musculus

Also known as 2310045A07Rik

Gene ID: 66402 | Gene type: protein coding

About Sln

Summary

Sarcoplasmic reticulum CA(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of CA(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum CA(2+)-ATPases. The transmembrane protein interacts with CA(2+)-ATPases and reduces the accumulation of CA(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

Sln Products(1)

mRNA	Protein	Name
NM_025540.2	NP_079816.1	sarcolipin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27923914	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	27923914	MGI
acts upstream of or within negative regulation of calcium ion binding	IDA IDA: Inferred from direct assay	27923914	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22961106	MGI
involved in regulation of ATPase-coupled calcium transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21697544	MGI
involved in regulation of relaxation of muscle	IMP IMP: Inferred from mutant phenotype	21697544	MGI
involved in sarcoplasmic reticulum calcium ion transport	IMP IMP: Inferred from mutant phenotype	21697544	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	27923914	MGI
located in sarcoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26816378	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sarcolipin

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147425	Zerlasiran	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147425A	Zerlasiran sodium	Inhibitor	95.52%	Unkown
HY-113217	Cholesteryl oleate		≥99.0%	Unkown
HY-113217S	Cholesteryl oleate-d7		≥99.0%	Unkown
HY-W013122	Cholesteryl n-butyrate		99.75%	Unkown
HY-113217S1	Cholesteryl oleate-d7-1		/	Unkown
HY-147278	Manusiran	Inhibitor	/	Unkown
HY-147278A	Manusiran sodium	Inhibitor	/	Unkown
HY-164390	6′SLN		/	Unkown
HY-RS13381	SLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168392	Propylene glycol monopalmitate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sln	NCBI	NCBI:6588
Macaca fascicularis	Sln	NCBI	NCBI:102131807
Rattus norvegicus	Sln	NCBI	NCBI:367086

Name
Email *

	Sorry, but the email address you supplied was invalid.