WNT2B - Wnt family member 2B Gene

Homo sapiens

Also known as WNT13

Gene ID: 7482 | Gene type: protein coding

About WNT2B

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,466,541-112,530,165 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a member of the wingless-type MMTV integration site (Wnt) family of highly conserved, secreted signaling factors. Wnt family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

WNT2B Products(3)

mRNA	Protein	Name
NM_001291880.1	NP_001278809.1	protein Wnt-2b isoform 3
NM_004185.4	NP_004176.2	protein Wnt-2b isoform WNT-2B1
NM_024494.3	NP_078613.1	protein Wnt-2b isoform WNT-2B2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11741304	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15135146	GOA
involved in chondrocyte differentiation	IEP IEP: Inferred from expression pattern	15135146	GOA
involved in forebrain regionalization	IEP IEP: Inferred from expression pattern	15164427	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9787155	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	17848411	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT2B Protein Structure

wnt

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

protein Wnt-2b

XWNT2, Xenopus, homolog of

Related Diseases

Diseases

Alias

Diarrhea 9

DIAR9

Diarrhea, Type 9

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Osmotic Diarrhea

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15833	WNT2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WNT2B	VGNC	VGNC:36958
Macaca mulatta	WNT2B	VGNC	VGNC:78797
Rattus norvegicus	WNT2B	RGD	RGD:69346
Felis catus	WNT2B	VGNC	VGNC:80403
Mus musculus	WNT2B	MGD	MGI:1261834
Canis familiaris	WNT2B	VGNC	VGNC:48423

Name
Email *

	Sorry, but the email address you supplied was invalid.