IL1R2 - interleukin 1 receptor type 2 Gene

Homo sapiens

Also known as IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2

Gene ID: 7850 | Gene type: protein coding

About IL1R2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,991,960-102,028,544 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 10 paralogues. Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three Other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

IL1R2 Products(2)

mRNA	Protein	Name
NM_001261419.2	NP_001248348.1	interleukin-1 receptor type 2 isoform 2 precursor
NM_004633.4	NP_004624.1	interleukin-1 receptor type 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1830582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1R2 Protein Structure

Ig_2

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor type 2

CD121 antigen-like family member B

Recombinant IL1R2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72567	IL-1R2 Protein, Human (HEK293, His)	P27930/NP_004624.1 (F14-E343)	≥95%
HY-P75849	IL-1R2 Protein, Human (HEK293)	P27930 (F14-E343)	≥95%
HY-P77701	IL-1R2 Protein, Human (HEK293, Fc)	P27930 (F14-E343)	≥95%

Related Diseases

Diseases

Alias

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06721	IL1R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL1R2	VGNC	VGNC:30132
Canis familiaris	IL1R2	VGNC	VGNC:41959
Rattus norvegicus	IL1R2	RGD	RGD:621147
Mus musculus	IL1R2	MGD	MGI:96546
Felis catus	IL1R2	VGNC	VGNC:67767
Macaca mulatta	IL1R2	VGNC	VGNC:73717
Others	IL1R2	NCBI

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