HROB - homologous recombination factor with OB-fold Gene

Homo sapiens

Also known as MCM8IP; C17orf53

Gene ID: 78995 | Gene type: protein coding

About HROB

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,141,930-44,162,476 (from NCBI)

This gene has 5 transcripts (splice variants) and 188 orthologues. Broad expression in testis (RPKM 4.5), bone marrow (RPKM 2.8) and 14 other tissues.

Summary

Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HROB Products(4)

mRNA	Protein	Name
NM_001171251.3	NP_001164722.1	homologous recombination OB-fold protein isoform 2
NM_001321310.2	NP_001308239.1	homologous recombination OB-fold protein isoform 3
NM_001321311.2	NP_001308240.1	homologous recombination OB-fold protein isoform 4
NM_024032.5	NP_076937.2	homologous recombination OB-fold protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31467087	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	31467087	GOA
involved in DNA synthesis involved in DNA repair	IMP IMP: Inferred from mutant phenotype	31467087	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	31467087	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	31467087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homologous recombination OB-fold protein

MCM8-9-Interacting Protein)

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06373	HROB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HROB	VGNC	VGNC:70421
Bos taurus	HROB	VGNC	VGNC:52654
Felis catus	HROB	VGNC	VGNC:60725
Rattus norvegicus	HROB	RGD	RGD:1305385
Canis familiaris	HROB	VGNC	VGNC:49206
Mus musculus	HROB	MGD	MGI:2387601
Others	HROB	NCBI

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