2. Gene
  3. HSD17B8 - hydroxysteroid 17-beta dehydrogenase 8 Gene

HSD17B8 - hydroxysteroid 17-beta dehydrogenase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9

Gene ID: 7923 | Gene type: protein coding

About HSD17B8

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,204,655-33,206,831 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 187 orthologues and 25 paralogues. Ubiquitous expression in liver (RPKM 17.4), kidney (RPKM 16.9) and 25 other tissues.

Summary

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative Enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the Enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

HSD17B8 Products(1)

mRNA Protein Name
NM_014234.5 NP_055049.1 (3R)-3-hydroxyacyl-CoA dehydrogenase

HSD17B8 Protein Structure

adh_short

adh_short: short chain dehydrogenase (14 - 187)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

(3R)-3-hydroxyacyl-CoA dehydrogenase

17-beta-HSD 8

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Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06400 HSD17B8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HSD17B8 VGNC VGNC:73466
Mus musculus HSD17B8 MGD MGI:95911
Bos taurus HSD17B8 VGNC VGNC:29977
Canis familiaris HSD17B8 VGNC VGNC:41810
Felis catus HSD17B8 VGNC VGNC:108364
Rattus norvegicus HSD17B8 RGD RGD:1303158