RIC3 - RIC3 acetylcholine receptor chaperone Gene

Homo sapiens

Also known as RIC-3; AYST720; PRO1385

Gene ID: 79608 | Gene type: protein coding

About RIC3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,092,965-8,169,025 (from NCBI)

This gene has 13 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in brain (RPKM 6.2), prostate (RPKM 4.2) and 23 other tissues.

Summary

This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

RIC3 Products(9)

mRNA	Protein	Name
NM_001135109.4	NP_001128581.1	protein RIC-3 isoform f precursor
NM_001206671.4	NP_001193600.1	protein RIC-3 isoform a precursor
NM_001206672.4	NP_001193601.1	protein RIC-3 isoform e precursor
NM_001346690.2	NP_001333619.1	protein RIC-3 isoform h
NM_001346691.2	NP_001333620.1	protein RIC-3 isoform i precursor
NM_001346692.2	NP_001333621.1	protein RIC-3 isoform j
NM_001346693.2	NP_001333622.1	protein RIC-3 isoform k
NM_001346694.2	NP_001333623.1	protein RIC-3 isoform g
NM_024557.6	NP_078833.3	protein RIC-3 isoform c precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	32204458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIC3 Protein Structure

RIC3

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

protein RIC-3

resistance to inhibitors of cholinesterase 3

Related Diseases

Diseases

Alias

Retinal Dystrophy And Obesity

RDOB	Dystrophy, Retinal, And Obesity

Tremor, Hereditary Essential, 3

ETM3	Essential Tremor 3
Essential Tremor, Hereditary, 3	Hereditary Essential Tremor 3

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11966	RIC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RIC3	MGD	MGI:2443887
Canis familiaris	RIC3	VGNC	VGNC:45571
Felis catus	RIC3	VGNC	VGNC:104324
Rattus norvegicus	RIC3	RGD	RGD:1588939
Bos taurus	RIC3	VGNC	VGNC:33960
Macaca mulatta	RIC3	VGNC	VGNC:76872

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