1. Gene
  2. ZFHX4 - zinc finger homeobox 4 Gene

ZFHX4 - zinc finger homeobox 4 Gene

Homo sapiens

Also known as ZFH4; ZHF4

Gene ID: 79776 | Gene type: protein coding

About ZFHX4

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:76,681,247-76,867,281 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZFHX4 Products(2)

mRNA Protein Name
NM_001410934.1 NP_001397863.1 zinc finger homeobox protein 4 isoform 2
NM_024721.5 NP_078997.4 zinc finger homeobox protein 4 isoform 1

ZFHX4 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (645 - 667)

zf-met

zf-met: Zinc-finger of C2H2 type (699 - 723)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1593 - 1617)

Homeobox

Homeobox: Homeobox domain (2130 - 2186)

Homeobox

Homeobox: Homeobox domain (2227 - 2283)

Homeobox

Homeobox: Homeobox domain (2606 - 2662)

Homeobox

Homeobox: Homeobox domain (2930 - 2986)

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  • 3616 a.a.
Protein Preferred Names Protein Names

zinc finger homeobox protein 4

zinc-finger homeodomain protein 4

Related Diseases

Diseases Alias
Ptosis, Hereditary Congenital 1

Ptosis, Hereditary Congenital, 1

PTOS1

Ptosis, Hereditary Congenital, Type 1

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Marcus Gunn Phenomenon

Jaw-Winking Syndrome

Marcus-Gunn Syndrome

Jaw-Winking

Maxillopalpebral Synkinesis

Abnormal Innervation Syndrome Of Eyelid

Jaw-Blinking

Pterygoid-Levator Synkinesis

Familial Marcus Gunn Phenomenon

Marcus Gunn Syndrome

Mandibulo-Palpebral Synkinesis-Ptosis Syndrome

Marcus-Gunn Phenomenon

Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome

Del(8)(Q21.11)

Deletion 8q21.11

Monosomy 8q21.11

Peters-Plus Syndrome

Krause-Kivlin Syndrome

Peters Plus Syndrome

Peters Anomaly

Irido-Corneo-Trabecular Dysgenesis

PTRPLS

Peters Anomaly With Short-Limb Dwarfism

Peters Anomaly-Short Limb Dwarfism Syndrome

Peters Anomaly With Short Limb Dwarfism

Peters Congenital Glaucoma

Krause-Van Schooneveld-Kivlin Syndrome

Peters' Plus Syndrome

Peters'-Plus Syndrome

Anomaly Peters

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus ZFHX4 VGNC VGNC:67229
Canis familiaris ZFHX4 VGNC VGNC:48608
Rattus norvegicus ZFHX4 RGD RGD:1563022
Macaca mulatta ZFHX4 VGNC VGNC:79902
Mus musculus ZFHX4 MGD MGI:2137668
Bos taurus ZFHX4 VGNC VGNC:37158