2. Gene
  3. LPCAT1 - lysophosphatidylcholine acyltransferase 1 Gene

LPCAT1 - lysophosphatidylcholine acyltransferase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT

Gene ID: 79888 | Gene type: protein coding

About LPCAT1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,461,427-1,523,960 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 249 orthologues and 4 paralogues. Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues.

Summary

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate Acyltransferase family of proteins. The encoded Enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

LPCAT1 Products(1)

mRNA Protein Name
NM_024830.5 NP_079106.3 lysophosphatidylcholine acyltransferase 1

LPCAT1 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (115 - 233)

EF-hand_6

EF-hand_6: EF-hand domain (384 - 409)

EF-hand_8

EF-hand_8: EF-hand domain pair (432 - 482)

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  • 534 a.a.
Protein Preferred Names Protein Names

lysophosphatidylcholine acyltransferase 1

1-acylglycerol-3-phosphate O-acyltransferase

Related Diseases

Diseases Alias
Epithelioid Trophoblastic Tumor

Trophoblastic Tumor, Epithelioid
Newborn Respiratory Distress Syndrome

Hyaline Membrane Disease

Respiratory Distress Syndrome Of Newborn

Neonatal Respiratory Distress

Hmd - Hyaline Membrane Disease

Neonatal Respiratory Distress Syndrome

Pulmonary Hyaline Membrane Disease

Pulmonary Hypoperfusion Syndrome Of Newborn

Respiratory Distress Syndrome, Newborn

Respiratory Distress Syndrome

Cardiorespiratory Distress Syndrome Of Newborn

Distress Respiratory Syndrome Newborn

Idiopathic Respiratory Distress Syndrome

Idiopathic Respiratory Distress Syndrome Of Newborn

Newborn Idiopathic Respiratory Distress Syndrome

Respiratory Distress Syndrome In Newborn

Rds - [Respiratory Distress Syndrome] Of Newborn

Newborn Cardiorespiratory Distress Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112825 TSI-01 98.31% Unkown
HY-RS07764 LPCAT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LPCAT1 RGD RGD:1311599
Mus musculus LPCAT1 MGD MGI:2384812
Macaca mulatta LPCAT1 VGNC VGNC:74361
Felis catus LPCAT1 VGNC VGNC:63264
Bos taurus LPCAT1 VGNC VGNC:30961
Canis familiaris LPCAT1 VGNC VGNC:42748