FZD9 - frizzled class receptor 9 Gene

Homo sapiens

Also known as FZD3; CD349

Gene ID: 8326 | Gene type: protein coding

About FZD9

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,433,778-73,436,120 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

FZD9 Products(1)

mRNA	Protein	Name
NM_003508.3	NP_003499.1	frizzled-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	19038973	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27509850	GOA
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	27509850	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27509850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	20458727	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19038973	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19038973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD9 Protein Structure

Frizzled

0
100
200
300
400
500
591 a.a.

Protein Preferred Names

Protein Names

frizzled-9

frizzled 9, seven transmembrane spanning receptor

Related Diseases

Diseases

Alias

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Osteopathia Striata With Cranial Sclerosis

Hyperostosis Generalisata With Striations	Robinow-Unger Syndrome
OSCS	Osteopathia Striata Cranial Sclerosis
Osteopathia Striata-Cranial Sclerosis Syndrome	Horan-Beighton Syndrome
Os-Cs	Osteopathia Striata - Cranial Sclerosis
Voorhoeve Disease	Osc

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05185	FZD9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FZD9	VGNC	VGNC:62407
Macaca mulatta	FZD9	VGNC	VGNC:81313
Canis familiaris	FZD9	VGNC	VGNC:41035
Bos taurus	FZD9	VGNC	VGNC:29172
Mus musculus	FZD9	MGD	MGI:1313278
Rattus norvegicus	FZD9	RGD	RGD:628817
Others	FZD9	NCBI

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