Ppargc1a - PPARG coactivator 1 alpha Gene

Rattus norvegicus

Also known as PGCvf; LRPGC1; PGC-1v; PGCvf1; PGCvf-1; Ppargc1

Gene ID: 83516 | Gene type: protein coding

About Ppargc1a

Primary_assembly 14: 58,861,144-59,512,656 forward strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 65 phenotypes. Biased expression in Kidney (RPKM 186.), Heart (RPKM 141.9) and 7 other tissues.

Summary

Enables several functions, including alpha-tubulin binding activity; Estrogen Receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); placental insufficiency; primary biliary cholangitis; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppargc1a Products(2)

mRNA	Protein	Name
NM_031347.1	NP_112637.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha
NM_031347.1	NP_112637.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	23297307	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	22705949	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	18511507	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	22464285	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	19948729	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19940161	RGD
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12107181	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adaptive thermogenesis	IEP IEP: Inferred from expression pattern	20363363	RGD
involved in androgen metabolic process	IEP IEP: Inferred from expression pattern	23338851	RGD
involved in autophagy of mitochondrion	IEP IEP: Inferred from expression pattern	19783904	RGD
involved in cellular response to caffeine	IEP IEP: Inferred from expression pattern	17516843	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	19786068	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	22676303	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IDA IDA: Inferred from direct assay	18511507	RGD
involved in cellular response to fructose stimulus	IEP IEP: Inferred from expression pattern	21212096	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	23692924	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	22527940	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	23692924	RGD
involved in cellular response to ionomycin	IEP IEP: Inferred from expression pattern	17516843	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19853624	RGD
involved in cellular response to nitrite	IEP IEP: Inferred from expression pattern	22892143	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	17870059	RGD
involved in cellular response to resveratrol	IEP IEP: Inferred from expression pattern	20438809	RGD
involved in cellular response to thyroid hormone stimulus	IDA IDA: Inferred from direct assay	19948729	RGD
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	23209300	RGD
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	18511507	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	22343369	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	17335037	RGD
involved in fatty acid oxidation	IEP IEP: Inferred from expression pattern	17869249	RGD
involved in flavone metabolic process	IEP IEP: Inferred from expression pattern	22767158	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	17335037	RGD
involved in galactose metabolic process	IEP IEP: Inferred from expression pattern	23022596	RGD
involved in gluconeogenesis	IEP IEP: Inferred from expression pattern	21212096	RGD
involved in mitochondrion organization	IEP IEP: Inferred from expression pattern	21543634	RGD
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	17099248	RGD
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	22343369	RGD
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	23449689	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19786068	RGD
involved in negative regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	22593067	RGD
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	19142226	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19142226	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16139565	RGD
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	16139565	RGD
involved in positive regulation of podocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	23692924	RGD
involved in positive regulation of progesterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	20133449	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20133449	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22527940	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	22593067	RGD
involved in response to L-leucine	IEP IEP: Inferred from expression pattern	22612562	RGD
involved in response to activity	IDA IDA: Inferred from direct assay	19273580	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	20433743	RGD
involved in response to dehydroepiandrosterone	IEP IEP: Inferred from expression pattern	22523357	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	20375275	RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation	IEP IEP: Inferred from expression pattern	15716393	RGD
involved in response to epinephrine	IEP IEP: Inferred from expression pattern	19221126	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	23269653	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	22523357	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	20875806	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	21302669	RGD
involved in response to methionine	IEP IEP: Inferred from expression pattern	17716000	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	23462817	RGD
involved in response to norepinephrine	IEP IEP: Inferred from expression pattern	23443926	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	26394137	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	22773756	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	23104933	RGD
involved in response to reactive oxygen species	IEP IEP: Inferred from expression pattern	16916551	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	22117073	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	15605382	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22343369	RGD
involved in skeletal muscle atrophy	IEP IEP: Inferred from expression pattern	16870628	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	17335037	RGD
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	17870059	RGD
located in euchromatin	IDA IDA: Inferred from direct assay	17870059	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17335037	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppargc1a Protein Structure

RRM_PPARGC1A

0
200
400
600
831 a.a.

Protein Preferred Names

Protein Names

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

PGC-1-alpha	PGC-1alpha
PPAR gamma coactivator 1alpha variant form-1	PPAR-gamma coactivator 1-alpha
PPARGC-1-alpha	Ppargc1a-vf1
peroxisome proliferative activated receptor gamma coactivator 1	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10930	Ppargc1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10928	PPARGC1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10929	Ppargc1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppargc1a	NCBI	NCBI:10891

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