SLITRK6 - SLIT and NTRK like family member 6 Gene

Homo sapiens

Also known as DFNMYP

Gene ID: 84189 | Gene type: protein coding

About SLITRK6

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:85,792,790-85,799,419 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 25 paralogues and is associated with 4 phenotypes. Biased expression in urinary bladder (RPKM 12.2), salivary gland (RPKM 7.4) and 11 other tissues.

Summary

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with Trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]

SLITRK6 Products(1)

mRNA	Protein	Name
NM_032229.3	NP_115605.2	SLIT and NTRK-like protein 6 precursor

SLITRK6 Protein Structure

LRR_8

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

SLIT and NTRK-like protein 6

4832410J21Rik

Recombinant SLITRK6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77208	SLITRK6 Protein, Human (HEK293, His)	Q9H5Y7 (S27-S608)	≥95%

Related Diseases

Diseases

Alias

Deafness And Myopia

High Myopia-Sensorineural Deafness Syndrome	DFNMYP
Deafness And Myopia Syndrome	Deafness, Cochlear, Plus
High Myopia And Sensorineural Deafness	Myopia And Deafness
High Myopia-Sensorineural Hearing Loss Syndrome

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Deafness, Autosomal Dominant 33

DFNA33	Autosomal Dominant Nonsyndromic Deafness 33
Autosomal Dominant Deafness 33

Autosomal Dominant Nonsyndromic Deafness 74

Dfna74

Renal Pelvis Carcinoma

Malignant Neoplasm Of Renal Pelvis	Malignant Tumor Of Renal Pelvis
Carcinoma Of Kidney Pelvis	Malignant Renal Pelvis Neoplasm
Renal Pelvis Cancer

Trichotillomania

TTM	Hair-Pulling Syndrome
Compulsive Hair Plucking	Hair Pulling Disorder

Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet	Supratentorial Embryonal Tumor, Not Otherwise Specified
Ewings Sarcoma-Primitive Neuroectodermal Tumor

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13378	SLITRK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLITRK6	VGNC	VGNC:46511
Macaca mulatta	SLITRK6	VGNC	VGNC:77763
Bos taurus	SLITRK6	VGNC	VGNC:34967
Mus musculus	SLITRK6	MGD	MGI:2443198
Rattus norvegicus	SLITRK6	RGD	RGD:1306550
Others	SLITRK6	NCBI

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