SLC25A33 - solute carrier family 25 member 33 Gene

Homo sapiens

Also known as PNC1; BMSC-MCP

Gene ID: 84275 | Gene type: protein coding

About SLC25A33

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,539,465-9,585,173 (from NCBI)

This gene has 1 transcript (splice variant), 198 orthologues and 49 paralogues. Broad expression in testis (RPKM 27.8), fat (RPKM 18.2) and 23 other tissues.

Summary

SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

SLC25A33 Products(1)

mRNA	Protein	Name
NM_032315.3	NP_115691.1	solute carrier family 25 member 33

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables pyrimidine nucleotide transmembrane transporter activity	IDA IDA: Inferred from direct assay	17596519	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	17596519	GOA
involved in cellular response to insulin-like growth factor stimulus	IDA IDA: Inferred from direct assay	17596519	GOA
involved in mitochondrial genome maintenance	IDA IDA: Inferred from direct assay	25320081	GOA
involved in mitochondrial respiratory chain complex III assembly	IMP IMP: Inferred from mutant phenotype	20453889	GOA
involved in mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	20453889	GOA
involved in mitochondrion organization	IDA IDA: Inferred from direct assay	25320081	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20453889	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	17596519	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17596519	GOA
involved in pyrimidine nucleotide import into mitochondrion	IMP IMP: Inferred from mutant phenotype	17596519	GOA
involved in pyrimidine nucleotide transport	IDA IDA: Inferred from direct assay	25320081	GOA
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	25320081	GOA
involved in regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	20453889	GOA
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	20453889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A33 Protein Structure

Mito_carr

0
100
200
300
321 a.a.

Protein Preferred Names

Protein Names

solute carrier family 25 member 33

bone marrow stromal cell mitochondrial carrier protein

Related Diseases

Diseases

Alias

Schnyder Corneal Dystrophy

Schnyder Crystalline Corneal Dystrophy	SCCD
Corneal Dystrophy, Crystalline, Of Schnyder	Corneal Dystrophy, Schnyder Type
Corneal Dystrophy Crystalline Of Schnyder	Crystalline Stromal Dystrophy
Hereditary Crystalline Stromal Dystrophy Of Schnyder	Scd
Corneal Dystrophy, Schnyder	Schnyder Crystalline Dystrophy Sine Crystals
Dystrophy, Corneal, Crystalline, Schnyder

Orofaciodigital Syndrome Viii

Edwards Syndrome	Trisomy 18
Complete Trisomy 18 Syndrome	OFD8
Orofaciodigital Syndrome 8	Trisomy 18 Syndrome
Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis	E3 Trisomy
Oral-Facial-Digital Syndrome Type 8	Orofaciodigital Syndrome Type 8
Ofds Viii	Oral-Facial-Digital Syndrome, Type Viii
Ofd Syndrome 8	Ofds 8
Oral Facial Digital Syndrome 8	Oral Facial Digital Syndrome Type 8
18 Trisomy	Chromosome 18 Trisomy
Trisomy 16-18	Trisomy E
Trisomy E Syndrome	Chromosome 18 Duplication
Oral-Facial-Digital Syndrome, Edwards Type	Orofaciodigital Syndrome, Edwards Type
Chromosome 18, Trisomy	Cleft Lip/Palate With Abnormal Thumbs And Microcephaly
Trisomy 18 Chromosome	Abnormal Autosomes 18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13115	SLC25A33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC25A33	MGD	MGI:1917806
Bos taurus	SLC25A33	VGNC	VGNC:34759
Canis familiaris	SLC25A33	VGNC	VGNC:46307
Rattus norvegicus	SLC25A33	RGD	RGD:1583942
Felis catus	SLC25A33	VGNC	VGNC:65270

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