SLITRK2 - SLIT and NTRK like family member 2 Gene

Homo sapiens

Also known as CXorf1; CXorf2; SLITL1; TMEM257

Gene ID: 84631 | Gene type: protein coding

About SLITRK2

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:145,817,829-145,829,856 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 25 paralogues. Biased expression in brain (RPKM 6.9), spleen (RPKM 1.8) and 2 other tissues.

Summary

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

SLITRK2 Products(8)

mRNA	Protein	Name
NM_001144003.3	NP_001137475.1	SLIT and NTRK-like protein 2 precursor
NM_001144004.3	NP_001137476.1	SLIT and NTRK-like protein 2 precursor
NM_001144005.3	NP_001137477.1	SLIT and NTRK-like protein 2 precursor
NM_001144006.2	NP_001137478.1	SLIT and NTRK-like protein 2 precursor
NM_001144008.2	NP_001137480.1	SLIT and NTRK-like protein 2 precursor
NM_001144009.2	NP_001137481.1	SLIT and NTRK-like protein 2 precursor
NM_001144010.2	NP_001137482.1	SLIT and NTRK-like protein 2 precursor
NM_032539.5	NP_115928.1	SLIT and NTRK-like protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35840571	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	35840571	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	27273464	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	27273464	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
located in dendrite	IDA IDA: Inferred from direct assay	35840571	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	35840571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK2 Protein Structure

LRR_8

0
200
400
600
845 a.a.

Protein Preferred Names

Protein Names

SLIT and NTRK-like protein 2

slit and trk like gene 2

Related Diseases

Diseases

Alias

Penile Benign Neoplasm

Neoplasm Of Penis	Penile Tumor
Cancer Of Penis	Carcinoma Of Penis
Malignant Neoplasm Of Penis, Unspecified	Malignant Neoplasm Of Penis, Part Unspecified
Malignant Tumour Of Penis	Penile Cancer
Primary Malignant Neoplasm Of Penis	Malignant Neoplasm Of Skin Of Penis Nos

Trichotillomania

TTM	Hair-Pulling Syndrome
Compulsive Hair Plucking	Hair Pulling Disorder

Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet	Supratentorial Embryonal Tumor, Not Otherwise Specified
Ewings Sarcoma-Primitive Neuroectodermal Tumor

Male Reproductive Organ Benign Neoplasm

Progesterone-Receptor Positive Breast Cancer

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS13374	SLITRK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLITRK2	RGD	RGD:1561361
Bos taurus	SLITRK2	VGNC	VGNC:34963
Canis familiaris	SLITRK2	VGNC	VGNC:46507
Mus musculus	SLITRK2	MGD	MGI:2679449
Macaca mulatta	SLITRK2	VGNC	VGNC:77690

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