RGS5 - regulator of G protein signaling 5 Gene

Homo sapiens

Also known as MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129

Gene ID: 8490 | Gene type: protein coding

About RGS5

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:163,142,299-163,321,735 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues.

Summary

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

RGS5 Products(12)

mRNA	Protein	Name
NM_001195303.3	NP_001182232.1	regulator of G-protein signaling 5 isoform 2
NM_001254748.2	NP_001241677.1	regulator of G-protein signaling 5 isoform 2
NM_001254749.2	NP_001241678.1	regulator of G-protein signaling 5 isoform 3
NM_001414472.1	NP_001401401.1	regulator of G-protein signaling 5 isoform 5
NM_001414473.1	NP_001401402.1	regulator of G-protein signaling 5 isoform 5
NM_001414474.1	NP_001401403.1	regulator of G-protein signaling 5 isoform 5
NM_001414475.1	NP_001401404.1	regulator of G-protein signaling 5 isoform 5
NM_001414476.1	NP_001401405.1	regulator of G-protein signaling 5 isoform 4
NM_001414477.1	NP_001401406.1	regulator of G-protein signaling 5 isoform 2
NM_001414478.1	NP_001401407.1	regulator of G-protein signaling 5 isoform 2
NM_001414479.1	NP_001401408.1	regulator of G-protein signaling 5 isoform 2
NM_003617.4	NP_003608.1	regulator of G-protein signaling 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS5 Protein Structure

RGS

0
100
181 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 5

regulator of G-protein signalling 5

RGS5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS5	O15539	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RGS5	O15539	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RGS5	O15539	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RGS5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74596	RGS5 Protein, Human (His)	O15539 (M1-K181)	≥95%

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11923	RGS5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGS5	MGD	MGI:1098434
Canis familiaris	RGS5	VGNC	VGNC:53128
Rattus norvegicus	RGS5	RGD	RGD:3568
Macaca mulatta	RGS5	VGNC	VGNC:100056
Bos taurus	RGS5	VGNC	VGNC:55670
Others	RGS5	NCBI

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