TANC1 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Gene

Homo sapiens

Also known as TANC; ROLSB

Gene ID: 85461 | Gene type: protein coding

About TANC1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:158,968,640-159,232,659 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 16.4), lung (RPKM 9.9) and 24 other tissues.

Summary

Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

TANC1 Products(6)

mRNA	Protein	Name
NM_001145909.2	NP_001139381.1	protein TANC1 isoform 2
NM_001350062.2	NP_001336991.1	protein TANC1 isoform 3
NM_001350063.2	NP_001336992.1	protein TANC1 isoform 4
NM_001350064.2	NP_001336993.1	protein TANC1 isoform 5
NM_001350065.2	NP_001336994.1	protein TANC1 isoform 5
NM_033394.3	NP_203752.2	protein TANC1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30126976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANC1 Protein Structure

Ank_2

Ank

TPR_11

TPR_2

0
300
600
900
1200
1500
1861 a.a.

Protein Preferred Names

Protein Names

protein TANC1

TPR domain, ankyrin-repeat and coiled-coil-containing

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 41

MRD41	Autosomal Dominant Non-Syndromic Intellectual Disability 41
Mental Retardation, Autosomal Dominant 41	Autosomal Dominant Intellectual Developmental Disorder 41
Autosomal Dominant Mental Retardation 41	Mental Retardation, Autosomal Dominant, Type 41

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14194	TANC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TANC1	VGNC	VGNC:35591
Macaca mulatta	TANC1	VGNC	VGNC:78238
Mus musculus	TANC1	MGD	MGI:1914110
Canis familiaris	TANC1	VGNC	VGNC:47098
Felis catus	TANC1	VGNC	VGNC:65948
Rattus norvegicus	TANC1	RGD	RGD:1302949

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