DGAT1 - diacylglycerol O-acyltransferase 1 Gene

Homo sapiens

Also known as ARAT; DGAT; ARGP1; DIAR7

Gene ID: 8694 | Gene type: protein coding

About DGAT1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,314,584-144,326,852 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 262 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in small intestine (RPKM 98.7), duodenum (RPKM 96.5) and 20 other tissues.

Summary

This gene encodes an multipass transmembrane protein that functions as a key metabolic Enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This Enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

DGAT1 Products(1)

mRNA	Protein	Name
NM_012079.6	NP_036211.2	diacylglycerol O-acyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	18458083	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32433610	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23420847	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	32433610	GOA
involved in monoacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	28420705	GOA
acts upstream of or within triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	18458083	GOA
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	18238778	GOA
involved in very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	15308631	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	32433610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGAT1 Protein Structure

MBOAT

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

diacylglycerol O-acyltransferase 1

ACAT related gene product 1

Related Diseases

Diseases

Alias

Congenital Diarrhea 7 With Exudative Enteropathy

Congenital Chronic Diarrhea With Exudative Enteropathy	Congenital Chronic Diarrhea With Protein-Losing Enteropathy
Congenital Chronic Diarrhoea With Exudative Enteropathy	Congenital Chronic Diarrhoea With Protein-Losing Enteropathy
Congenital Diarrhoea 7 With Exudative Enteropathy

Diarrhea 7, Protein-Losing Enteropathy Type

DIAR7

Protein-Losing Enteropathy

Protein-Losing Enteropathies	Enteropathy, Exudative
Exudative Enteropathy	Ple - [Protein-Losing Enteropathy]

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Congenital Diarrhea

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16278	Pradigastat	Inhibitor	98.88%	Phase 3
HY-13009	PF-04620110	Inhibitor	98.86%	Phase 1
HY-15497	AZD7687	Inhibitor	99.80%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10038	A 922500	Inhibitor	99.33%	Unkown
HY-32219	T863	Inhibitor	99.97%	Unkown
HY-12425	DGAT1-IN-1	Inhibitor	≥98.0%	Unkown
HY-50861	AZD3988	Inhibitor	99.83%	Unkown
HY-50670	DGAT-1 inhibitor 2	Inhibitor	95.70%	Unkown
HY-141572	1,2-Dioleoyl-sn-glycerol		99.96%	Unkown
HY-16434	DGAT1-IN-3	Inhibitor	99.92%	Unkown
HY-15197	ABT-046	Inhibitor	98.13%	Unkown
HY-111417	GSK2973980A	Inhibitor	/	Unkown
HY-112851	Diacylglycerol acyltransferase inhibitor-1	Inhibitor	/	Unkown
HY-16278A	Pradigastat sodium	Inhibitor	/	Unkown
HY-N7281	Aphadilactone C	Inhibitor	/	Unkown
HY-RS03710	DGAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118386	H2-005		/	Unkown
HY-136707	DGAT-1 inhibitor 3	Inhibitor	/	Unkown
HY-16266	JNJ-DGAT1-A	Inhibitor	/	Unkown
HY-N9153A	Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DGAT1	VGNC	VGNC:61455
Rattus norvegicus	DGAT1	RGD	RGD:628673
Macaca mulatta	DGAT1	VGNC	VGNC:71776
Canis familiaris	DGAT1	VGNC	VGNC:39912
Mus musculus	DGAT1	MGD	MGI:1333825
Bos taurus	DGAT1	VGNC	VGNC:28020

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