TNFSF12 - TNF superfamily member 12 Gene

Homo sapiens

Also known as APO3L; DR3LG; TWEAK; TNLG4A

Gene ID: 8742 | Gene type: protein coding

About TNFSF12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,549,058-7,557,881 (from NCBI)

This gene has 20 transcripts (splice variants), 85 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce Apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12 Products(1)

mRNA	Protein	Name
NM_003809.3	NP_003800.1	tumor necrosis factor ligand superfamily member 12 proprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14961121	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21525013	GOA
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	17389268	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14961121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF12 Protein Structure

TNF

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 12

APO3 ligand

Recombinant TNFSF12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7309	TWEAK/TNFSF12 Protein, Human (CHO)	O43508-1/Q4ACW9 (R99-H249)	≥95%
HY-P77263	TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc)	F7HGN4 (S94-H249)	≥95%
HY-P700156AF	Animal-Free TWEAK/TNFSF12 Protein, Human (His)	O43508 (K97-H249)	≥95%
HY-P701045	TWEAK/TNFSF12 Protein, Human (HEK293, hFc)	O43508-1 (S43-H249)	≥95%

Related Diseases

Diseases

Alias

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Amnestic Disorder

Amnesia	Amnestic Syndrome
Korsakoff'S Psychosis Or Syndrome	Amnesic Syndrome
Amnestic Disorder In Conditions Classified Elsewhere	Korsakoff Psychosis Or Syndrome, Nonalcoholic
Nonalcoholic Organic Amnesic Syndrome	Organic Amnesic Syndrome

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14822	TNFSF12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF12	VGNC	VGNC:55878
Rattus norvegicus	TNFSF12	RGD	RGD:1359620
Mus musculus	TNFSF12	MGD	MGI:1196259
Macaca fascicularis	TNFSF12	NCBI	NCBI:102128998
Others	TNFSF12	NCBI

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