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  2. TNFSF12 - TNF superfamily member 12 Gene

TNFSF12 - TNF superfamily member 12 Gene

Homo sapiens

Also known as APO3L; DR3LG; TWEAK; TNLG4A

Gene ID: 8742 | Gene type: protein coding

About TNFSF12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,549,058-7,557,881 (from NCBI)

This gene has 20 transcripts (splice variants), 85 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce Apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12 Products(1)

mRNA Protein Name
NM_003809.3 NP_003800.1 tumor necrosis factor ligand superfamily member 12 proprotein

TNFSF12 Protein Structure

TNF

TNF: TNF(Tumour Necrosis Factor) family (132 - 248)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 12

APO3 ligand

Recombinant TNFSF12 Proteins

Cat. No. Product Name Accession Purity
HY-P7309 TWEAK/TNFSF12 Protein, Human (CHO) O43508-1/Q4ACW9 (R99-H249) ≥95%
HY-P77263 TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc) F7HGN4 (S94-H249) ≥95%
HY-P700156AF Animal-Free TWEAK/TNFSF12 Protein, Human (His) O43508 (K97-H249) ≥95%
HY-P701045 TWEAK/TNFSF12 Protein, Human (HEK293, hFc) O43508-1 (S43-H249) ≥95%

Related Diseases

Diseases Alias
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome

Amnestic Disorder

Amnesia

Amnestic Syndrome

Korsakoff'S Psychosis Or Syndrome

Amnesic Syndrome

Amnestic Disorder In Conditions Classified Elsewhere

Korsakoff Psychosis Or Syndrome, Nonalcoholic

Nonalcoholic Organic Amnesic Syndrome

Organic Amnesic Syndrome

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TNFSF12 VGNC VGNC:55878
Rattus norvegicus TNFSF12 RGD RGD:1359620
Mus musculus TNFSF12 MGD MGI:1196259
Macaca fascicularis TNFSF12 NCBI NCBI:102128998
Others TNFSF12 NCBI