RGS11 - regulator of G protein signaling 11 Gene

Homo sapiens

Also known as RS11

Gene ID: 8786 | Gene type: protein coding

About RGS11

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:268,307-275,944 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 23 paralogues. Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

RGS11 Products(4)

mRNA	Protein	Name
NM_001286485.2	NP_001273414.1	regulator of G-protein signaling 11 isoform 3
NM_001286486.2	NP_001273415.1	regulator of G-protein signaling 11 isoform 4
NM_003834.3	NP_003825.1	regulator of G-protein signaling 11 isoform 2
NM_183337.3	NP_899180.1	regulator of G-protein signaling 11 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein beta-subunit binding	IPI IPI: Inferred from physical interaction	12606627	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	18468998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS11 Protein Structure

DEP

G-gamma

RGS

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 11

regulator of G-protein signalling 11

Related Diseases

Diseases

Alias

Prolonged Electroretinal Response Suppression

Bradyopsia

PERRS

Bullous Retinoschisis

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11904	RGS11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGS11	MGD	MGI:1354739
Macaca mulatta	RGS11	VGNC	VGNC:76916
Canis familiaris	RGS11	VGNC	VGNC:45521
Felis catus	RGS11	VGNC	VGNC:69311
Bos taurus	RGS11	VGNC	VGNC:33912
Rattus norvegicus	RGS11	RGD	RGD:3563

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