IL18R1 - interleukin 18 receptor 1 Gene

Homo sapiens

Also known as CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha

Gene ID: 8809 | Gene type: protein coding

About IL18R1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,355,796-102,398,776 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 10 paralogues. Broad expression in appendix (RPKM 4.6), gall bladder (RPKM 3.7) and 21 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four Other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

IL18R1 Products(9)

mRNA	Protein	Name
NM_001282399.2	NP_001269328.1	interleukin-18 receptor 1 isoform 2
NM_001371418.1	NP_001358347.1	interleukin-18 receptor 1 isoform 3 precursor
NM_001371419.1	NP_001358348.1	interleukin-18 receptor 1 isoform 4 precursor
NM_001371420.1	NP_001358349.1	interleukin-18 receptor 1 isoform 5 precursor
NM_001371421.1	NP_001358350.1	interleukin-18 receptor 1 isoform 6
NM_001371422.1	NP_001358351.1	interleukin-18 receptor 1 isoform 7
NM_001371423.1	NP_001358352.1	interleukin-18 receptor 1 isoform 8
NM_001371424.1	NP_001358353.1	interleukin-18 receptor 1 isoform 8
NM_003855.5	NP_003846.1	interleukin-18 receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-18 binding	IDA IDA: Inferred from direct assay	14528293	GOA
enables interleukin-18 receptor activity	IDA IDA: Inferred from direct assay	25500532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25261253	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	25500532	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	25500532	GOA
involved in positive regulation of T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	10653850	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	10653850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of interleukin-18 receptor complex	IDA IDA: Inferred from direct assay	25500532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL18R1 Protein Structure

Ig_2

Ig_3

TIR

0
100
200
300
400
500
541 a.a.

Protein Preferred Names

Protein Names

interleukin-18 receptor 1

CD218 antigen-like family member A

IL18R1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL18R1	Q13478	IL18	Homo sapiens	Q14116	GMS	25261253

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL18R1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75842	IL-18R alpha Protein, Human (HEK293, Fc)	Q13478 (A19-R329)	≥95%
HY-P75843	IL-18R alpha Protein, Human (HEK293, His)	Q13478 (A19-R329)	≥95%
HY-P77710	IL-18R alpha Protein, Human (HEK293, His-Avi)	Q13478 (A19-R329)	≥95%
HY-P77711	IL-18R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	Q13478 (A19-R329)	≥95%

Related Diseases

Diseases

Alias

Laron Syndrome

Growth Hormone Insensitivity Syndrome	Growth Hormone Receptor Deficiency
Laron Dwarfism	Pituitary Dwarfism Ii
Laron-Type Isolated Somatotropin Defect	Primary Growth Hormone Resistance
Laron-Type Dwarfism	Laron Type Pituitary Dwarfism I
Primary Growth Hormone Insensitivity	Primary Gh Resistance
Gh-R Deficiency	Growth Hormone Receptor Defect
Laron-Type Pituitary Dwarfism	Laron-Type Short Stature
Severe Gh Insensitivity	Ghis
Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway	Complete Growth Hormone Insensitivity
Gh Receptor Deficiency	Primary Gh Insensitivity
Short Stature Due To Growth Hormone Resistance	LARS

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia	Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia
T-Cell Childhood Acute Lymphocytic Leukemia	Childhood T Lymphoblastic Leukemia/Lymphoma

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency	SCIDX1
XSCID	Scidx
X-Linked Scid	X-Scid
Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Scid, X-Linked
Immunodeficiency 4	Imd4
Gamma Chain Deficiency	Scid-X1
X-Linked Combined Immunodeficiency Diseases	Thymic Epithelial Hypoplasia
Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency	Severe Combined Immunodeficiency T- B+, X-Linked
Il2rg Scid, T- B+ Nk-	T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
T-B+ Scid Due To Gamma Chain Deficiency	T-B+ Severe Combined Immunodeficiency, X-Linked
Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative	Agammaglobulinemia Swiss Type
Scid X-Linked	Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative
Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative	Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Psoriasis

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06710	IL18R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL18R1	VGNC	VGNC:30127
Macaca mulatta	IL18R1	VGNC	VGNC:73714
Rattus norvegicus	IL18R1	RGD	RGD:1308589
Felis catus	IL18R1	VGNC	VGNC:67764
Canis familiaris	IL18R1	VGNC	VGNC:41953
Mus musculus	IL18R1	MGD	MGI:105383
Others	IL18R1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.