2. Gene
  3. INPP4B - inositol polyphosphate-4-phosphatase type II B Gene

INPP4B - inositol polyphosphate-4-phosphatase type II B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8821 | Gene type: protein coding

About INPP4B

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:142,023,160-142,846,535 (from NCBI)

This gene has 25 transcripts (splice variants), 254 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 24 other tissues.

Summary

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the Enzymes involved in phosphatidylinositol signaling pathways. This Enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II Enzyme is subject to alternative splicing, as has been established for the type I Enzyme. [provided by RefSeq, Jul 2008]

INPP4B Products(34)

mRNA Protein Name
NM_001101669.3 NP_001095139.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001331040.1 NP_001317969.1 inositol polyphosphate 4-phosphatase type II isoform 2
NM_001385334.1 NP_001372263.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385335.1 NP_001372264.1 inositol polyphosphate 4-phosphatase type II isoform 2
NM_001385336.1 NP_001372265.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385337.1 NP_001372266.1 inositol polyphosphate 4-phosphatase type II isoform 12
NM_001385338.1 NP_001372267.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385339.1 NP_001372268.1 inositol polyphosphate 4-phosphatase type II isoform 3
NM_001385340.1 NP_001372269.1 inositol polyphosphate 4-phosphatase type II isoform 14
NM_001385341.1 NP_001372270.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385342.1 NP_001372271.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385343.1 NP_001372272.1 inositol polyphosphate 4-phosphatase type II isoform 3
NM_001385344.1 NP_001372273.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385347.1 NP_001372276.1 inositol polyphosphate 4-phosphatase type II isoform 4
NM_001385348.1 NP_001372277.1 inositol polyphosphate 4-phosphatase type II isoform 4
NM_001385350.1 NP_001372279.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385351.1 NP_001372280.1 inositol polyphosphate 4-phosphatase type II isoform 6
NM_001385357.1 NP_001372286.1 inositol polyphosphate 4-phosphatase type II isoform 17
NM_001385362.1 NP_001372291.1 inositol polyphosphate 4-phosphatase type II isoform 18
NM_001385379.1 NP_001372308.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385380.1 NP_001372309.1 inositol polyphosphate 4-phosphatase type II isoform 13
NM_001385381.1 NP_001372310.1 inositol polyphosphate 4-phosphatase type II isoform 11
NM_001385382.1 NP_001372311.1 inositol polyphosphate 4-phosphatase type II isoform 9
NM_001385383.1 NP_001372312.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385450.1 NP_001372379.1 inositol polyphosphate 4-phosphatase type II isoform 15
NM_001385452.1 NP_001372381.1 inositol polyphosphate 4-phosphatase type II isoform 16
NM_001385454.1 NP_001372383.1 inositol polyphosphate 4-phosphatase type II isoform 19
NM_001385455.1 NP_001372384.1 inositol polyphosphate 4-phosphatase type II isoform 8
NM_001385457.1 NP_001372386.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385458.1 NP_001372387.1 inositol polyphosphate 4-phosphatase type II isoform 17
NM_001385459.1 NP_001372388.1 inositol polyphosphate 4-phosphatase type II isoform 7
NM_001385460.1 NP_001372389.1 inositol polyphosphate 4-phosphatase type II isoform 5
NM_001385461.1 NP_001372390.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_003866.3 NP_003857.2 inositol polyphosphate 4-phosphatase type II isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24407287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol polyphosphate 4-phosphatase type II

inositol polyphosphate 4-phosphatase II

Related Diseases

Diseases Alias
Achalasia

Cardiospasm

Achalasia Of Cardia

Esophageal Achalasia

Hypertensive Lower Esophageal Sphincter

Idiopathic Achalasia

Achalasia Cardia

Idiopathic Achalasia Of Esophagus

Primary Achalasia

Achalasia Of Esophagus

Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

Aperistalsis Of The Oesophagus

Achalasia Of Oesophagus

Oesophageal Achalasia

Achalasia Nos

Cardia Spasm

Cardia Achalasia

Oesophageal Cardiospasm

Oesophagus Achalasia

Reflex Cardiospasm
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06826 INPP4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta INPP4B VGNC VGNC:73748
Rattus norvegicus INPP4B RGD RGD:620470
Mus musculus INPP4B MGD MGI:2158925
Canis familiaris INPP4B VGNC VGNC:42029
Bos taurus INPP4B VGNC VGNC:53908
Felis catus INPP4B VGNC VGNC:67806