CDK5R2 - cyclin dependent kinase 5 regulatory subunit 2 Gene

Homo sapiens

Also known as P39; NCK5AI; p39nck5ai

Gene ID: 8941 | Gene type: protein coding

About CDK5R2

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,959,666-218,962,155 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 1 paralogue.

Summary

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

CDK5R2 Products(1)

mRNA	Protein	Name
NM_003936.5	NP_003927.1	cyclin-dependent kinase 5 activator 2

CDK5R2 Protein Structure

CDK5_activator

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5 activator 2

CDK5 activator 2

Related Diseases

Diseases

Alias

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02388	CDK5R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDK5R2	VGNC	VGNC:27129
Macaca mulatta	CDK5R2	VGNC	VGNC:70982
Rattus norvegicus	CDK5R2	RGD	RGD:1562530
Felis catus	CDK5R2	VGNC	VGNC:107505
Canis familiaris	CDK5R2	VGNC	VGNC:39056
Mus musculus	CDK5R2	MGD	MGI:1330828

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