Tnfsf4 - TNF superfamily member 4 Gene

Rattus norvegicus

Also known as Ox40l; Tnlg2b

Gene ID: 89814 | Gene type: protein coding

About Tnfsf4

Summary

Enables tumor necrosis factor receptor superfamily binding activity. Involved in T cell proliferation; positive regulation of activated T cell proliferation; and positive regulation of interleukin-2 production. Located in cell surface. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF Superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf4 Products(1)

mRNA	Protein	Name
NM_053552.2	NP_446004.1	tumor necrosis factor ligand superfamily member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tumor necrosis factor receptor superfamily binding	IMP IMP: Inferred from mutant phenotype	10772947	RGD
enables tumor necrosis factor receptor superfamily binding	IPI IPI: Inferred from physical interaction	9790919	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell proliferation	IMP IMP: Inferred from mutant phenotype	10772947	RGD
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	9790919	RGD
involved in positive regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	9790919	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9790919	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 4

OX40 ligand	tumor necrosis factor (ligand) superfamily, member 4
tumor necrosis factor ligand 2b	tumor necrosis factor superfamily member 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14828	TNFSF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990907	Brivekimig	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfsf4	NCBI	NCBI:7292
Macaca fascicularis	Tnfsf4	NCBI	NCBI:102141877
Mus musculus	Tnfsf4	NCBI	NCBI:22164
Leporidae	Tnfsf4	NCBI
Macaca mulatta	Tnfsf4	NCBI	NCBI:706255

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