SYT8 - synaptotagmin 8 Gene

Homo sapiens

Gene ID: 90019 | Gene type: protein coding

About SYT8

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,831,784-1,837,521 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 175 orthologues and 31 paralogues. Biased expression in skin (RPKM 28.8), urinary bladder (RPKM 7.9) and 5 other tissues.

Summary

This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the Insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to Insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

SYT8 Products(5)

mRNA	Protein	Name
NM_001290332.2	NP_001277261.2	synaptotagmin-8 isoform 1
NM_001290333.2	NP_001277262.2	synaptotagmin-8 isoform 3
NM_001290334.2	NP_001277263.2	synaptotagmin-8 isoform 4
NM_001394072.1	NP_001381001.1	synaptotagmin-8 isoform 5
NM_138567.5	NP_612634.4	synaptotagmin-8 isoform 2

SYT8 Protein Structure

0
100
200
300
401 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-8

synaptotagmin VIII

Related Diseases

Diseases

Alias

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b	Lgmd3
Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency	Limb-Girdle Muscular Dystrophy Type 3
Muscular Dystrophy, Limb-Girdle, Type 2b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14120	SYT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SYT8	VGNC	VGNC:78168
Canis familiaris	SYT8	VGNC	VGNC:47051
Mus musculus	SYT8	MGD	MGI:1859867
Rattus norvegicus	SYT8	RGD	RGD:68399
Bos taurus	SYT8	VGNC	VGNC:56284
Felis catus	SYT8	VGNC	VGNC:65903

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