UCN2 - urocortin 2 Gene

Homo sapiens

Also known as UR; SRP; URP; UCNI; UCN-II

Gene ID: 90226 | Gene type: protein coding

About UCN2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,561,718-48,563,781 (from NCBI)

This gene has 1 transcript (splice variant), 140 orthologues and 1 paralogue. Biased expression in skin (RPKM 5.7), endometrium (RPKM 1.2) and 4 other tissues.

Summary

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

UCN2 Products(1)

mRNA	Protein	Name
NM_033199.4	NP_149976.1	urocortin-2 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables corticotropin-releasing hormone receptor binding	IPI IPI: Inferred from physical interaction	11329063	GOA
enables hormone binding	IPI IPI: Inferred from physical interaction	11329063	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11329063	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	11329063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCN2 Protein Structure

0
100
112 a.a.

Protein Preferred Names

Protein Names

urocortin-2

prepro-urocortin 2

Related Diseases

Diseases

Alias

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15408	UCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UCN2	VGNC	VGNC:36638
Canis familiaris	UCN2	VGNC	VGNC:48109
Rattus norvegicus	UCN2	RGD	RGD:620765
Mus musculus	UCN2	MGD	MGI:2176375

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