SLC28A2 - solute carrier family 28 member 2 Gene

Homo sapiens

Also known as CNT2; HCNT2; SPNT1; HsT17153

Gene ID: 9153 | Gene type: protein coding

About SLC28A2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,252,234-45,277,846 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 43.4), duodenum (RPKM 31.3) and 4 other tissues.

Summary

Enables neurotransmitter transmembrane transporter activity and nucleoside transmembrane transporter activity. Involved in several processes, including nucleoside transport; purine nucleobase transmembrane transport; and pyrimidine-containing compound transmembrane transport. Predicted to be located in membrane. Predicted to be part of brush border membrane; coated vesicle; and vesicle membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC28A2 Products(1)

mRNA	Protein	Name
NM_004212.4	NP_004203.2	sodium/nucleoside cotransporter 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	10087507	GOA
enables nucleoside:sodium symporter activity	IDA IDA: Inferred from direct assay	10087507	GOA
enables purine nucleobase transmembrane transporter activity	IDA IDA: Inferred from direct assay	22492015	GOA
enables purine nucleoside transmembrane transporter activity	IDA IDA: Inferred from direct assay	10087507	GOA
enables pyrimidine- and adenosine-specific:sodium symporter activity	IDA IDA: Inferred from direct assay	10087507	GOA
enables uridine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10087507	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenosine transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in inosine transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in purine nucleobase transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA
involved in purine nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in pyrimidine-containing compound transmembrane transport	IDA IDA: Inferred from direct assay	10087507	GOA
involved in uridine transmembrane transport	IDA IDA: Inferred from direct assay	10087507	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC28A2 Protein Structure

Nucleos_tra2_N

Gate

Nucleos_tra2_C

0
200
400
600
658 a.a.

Protein Preferred Names

Protein Names

sodium/nucleoside cotransporter 2

CNT 2

Related Diseases

Diseases

Alias

Hyperuricemia

Blood Urate Raized

Uricacidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13151	SLC28A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC28A2	VGNC	VGNC:77445
Rattus norvegicus	SLC28A2	RGD	RGD:61840
Bos taurus	SLC28A2	VGNC	VGNC:34792

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