PPT2 - palmitoyl-protein thioesterase 2 Gene

Homo sapiens

Also known as G14; PPT-2; C6orf8

Gene ID: 9374 | Gene type: protein coding

About PPT2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,153,528-32,163,675 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 282 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 15.5), placenta (RPKM 11.9) and 25 other tissues.

Summary

This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]

PPT2 Products(3)

mRNA	Protein	Name
NM_001204103.2	NP_001191032.1	lysosomal thioesterase PPT2 isoform a precursor
NM_005155.7	NP_005146.4	lysosomal thioesterase PPT2 isoform a precursor
NM_138717.3	NP_619731.2	lysosomal thioesterase PPT2 isoform b precursor

PPT2 Protein Structure

Palm_thioest

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

lysosomal thioesterase PPT2

S-thioesterase G14

Related Diseases

Diseases

Alias

Neurotrophic Keratoconjunctivitis

Alzheimer Disease 9

AD9	Alzheimer'S Disease 9
Alzheimer Disease 9, Susceptibility To	Alzheimer Disease 9, Late-Onset
Alzheimer'S Disease 9, Late Onset	{Alzheimer Disease 9, Susceptibility To}

Giardiasis

Beaver Feaver	Infection By Giardia Lamblia
Lambliasis	Giardia Lamblia Dysentery
Giardial Diarrhoea	Lamblia Dysentery
Giardia Duodenalis Dysentery	Giardia Intestinalis Dysentery

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11039	PPT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPT2	VGNC	VGNC:102491
Mus musculus	PPT2	MGD	MGI:1860075
Bos taurus	PPT2	VGNC	VGNC:57311
Rattus norvegicus	PPT2	RGD	RGD:620375
Canis familiaris	PPT2	VGNC	VGNC:44930

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