2. Gene
  3. NCR1 - natural cytotoxicity triggering receptor 1 Gene

NCR1 - natural cytotoxicity triggering receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LY94; CD335; NKP46; NK-p46

Gene ID: 9437 | Gene type: protein coding

About NCR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,898,198-54,938,208 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues.

Summary

Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Apr 2022]

NCR1 Products(5)

mRNA Protein Name
NM_001145457.3 NP_001138929.2 natural cytotoxicity triggering receptor 1 isoform b precursor
NM_001145458.3 NP_001138930.2 natural cytotoxicity triggering receptor 1 isoform c precursor
NM_001242356.3 NP_001229285.1 natural cytotoxicity triggering receptor 1 isoform d precursor
NM_001242357.3 NP_001229286.1 natural cytotoxicity triggering receptor 1 isoform e precursor
NM_004829.7 NP_004820.2 natural cytotoxicity triggering receptor 1 isoform a precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17056548 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 117)

Ig_3

Ig_3: Immunoglobulin domain (124 - 193)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 1

NK cell-activating receptor

NCR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NCR1 O76036 P27918-PRO_0000035863 Homo sapiens P27918-PRO_0000035863
FACS
28480349
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR1 Proteins

Cat. No. Product Name Accession Purity
HY-P70174 NKp46/NCR1 Protein, Human (HEK293, Fc) O76036-6/AAH64806 (Q22-D254) ≥95%
HY-P77810 NKp46/NCR1 Protein, Human (HEK293, His) O76036-6/AAH64806 (Q22-D254) ≥95%
HY-P78008 NKp46/NCR1 Protein, Human (HEK293, mFc) O76036 (Q22-N255) ≥95%
HY-P78832 NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His) O76036 (Q22-N254) ≥95%

Related Diseases

Diseases Alias
Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos
Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole

Gestational Trophoblastic Disease

Complete Hydatidiform Mole

Hydm

HYDM1

Chm

Molar Pregnancy

Hydatidiform Mole, Complete

Hydatid Mole

Complete Molar Pregnancy

Mole, Hydatidiform, Recurrent, Type 1

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 2

Classical Hydatidiform Mole
Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales
Nk Cell Deficiency
Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest
Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome

AIDS

Acquired Immune Deficiency

Acquired Immunodeficiency

Acquired Immunodeficiency Due To Protein Loss
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Cd3zeta Deficiency
Bronchiectasis 1
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09098 NCR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCR1 RGD RGD:621288
Mus musculus NCR1 MGD MGI:1336212
Bos taurus NCR1 VGNC VGNC:31926
Canis familiaris NCR1 VGNC VGNC:53740
Macaca mulatta NCR1 VGNC VGNC:75065
Macaca fascicularis NCR1 NCBI NCBI:102115479
Others NCR1 NCBI