1. Gene
  2. IL27RA - interleukin 27 receptor subunit alpha Gene

IL27RA - interleukin 27 receptor subunit alpha Gene

Homo sapiens

Also known as CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1

Gene ID: 9466 | Gene type: protein coding

About IL27RA

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,031,762-14,053,218 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 641 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 12.2), appendix (RPKM 9.7) and 22 other tissues.

Summary

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

IL27RA Products(1)

mRNA Protein Name
NM_004843.4 NP_004834.1 interleukin-27 receptor subunit alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19386761 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19386761 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL27RA Protein Structure

fn3

fn3: Fibronectin type III domain (321 - 403)

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  • 636 a.a.
Protein Preferred Names Protein Names

interleukin-27 receptor subunit alpha

IL-27 receptor subunit alpha

IL27RA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL27RA Q6UWB1 SLC41A2 Homo sapiens Q96JW4 32296183
Intra
IL27RA Q6UWB1 DERL3 Homo sapiens Q96Q80 32296183
Intra
IL27RA Q6UWB1 MFSD5 Homo sapiens Q6N075 32296183
Intra
IL27RA Q6UWB1 GALNT15 Homo sapiens Q8N3T1 32296183
Intra
IL27RA Q6UWB1 YIPF6 Homo sapiens Q96EC8 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL27RA Proteins

Cat. No. Product Name Accession Purity
HY-P77223 IL-27R alpha/TCCR Protein, Human (HEK293, Fc) Q6UWB1 (Q33-R514) ≥95%
HY-P701013 IL-27R alpha/TCCR Protein, Human (HEK293, His) Q6UWB1 (G34-K516) ≥95%

Related Diseases

Diseases Alias
Hyper Ige Recurrent Infection Syndrome 4
Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2

CISS2

Sweating Syndrome, Cold-Induced, Type 2

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus IL27RA VGNC VGNC:30151
Rattus norvegicus IL27RA RGD RGD:1305029
Felis catus IL27RA VGNC VGNC:62910
Canis familiaris IL27RA VGNC VGNC:81272
Macaca mulatta IL27RA VGNC VGNC:73611
Mus musculus IL27RA MGD MGI:1355318
Others IL27RA NCBI