2. Gene
  3. ATP5MF - ATP synthase membrane subunit f Gene

ATP5MF - ATP synthase membrane subunit f Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ATP5J2; ATP5JL

Gene ID: 9551 | Gene type: protein coding

About ATP5MF

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,458,195-99,466,167 (from NCBI)

This gene has 12 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in colon (RPKM 103.6), kidney (RPKM 95.9) and 25 other tissues.

Summary

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]

ATP5MF Products(4)

mRNA Protein Name
NM_001003713.4 NP_001003713.1 ATP synthase subunit f, mitochondrial isoform 2b
NM_001003714.4 NP_001003714.1 ATP synthase subunit f, mitochondrial isoform 2c
NM_001039178.4 NP_001034267.1 ATP synthase subunit f, mitochondrial isoform 2d
NM_004889.5 NP_004880.1 ATP synthase subunit f, mitochondrial isoform 2a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence Reference Source
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence Reference Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5MF Protein Structure

WRW

WRW: Mitochondrial F1F0-ATP synthase, subunit f (14 - 90)

  • 0
  • 94 a.a.
Protein Preferred Names Protein Names

ATP synthase subunit f, mitochondrial

ATP synthase f chain, mitochondrial

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01209 ATP5MF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ATP5MF RGD RGD:1596067
Mus musculus ATP5MF MGD MGI:1927558
Bos taurus ATP5MF VGNC VGNC:26305