2. Gene
  3. TESPA1 - thymocyte expressed, positive selection associated 1 Gene

TESPA1 - thymocyte expressed, positive selection associated 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSPC257; ITPRID3; KIAA0748

Gene ID: 9840 | Gene type: protein coding

About TESPA1

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,948,015-54,985,188 (from NCBI)

This gene has 14 transcripts (splice variants), 190 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 4.0), brain (RPKM 4.0) and 13 other tissues.

Summary

Predicted to enable Phospholipase binding activity. Predicted to be involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within TCR signalosome assembly. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

TESPA1 Products(12)

mRNA Protein Name
NM_001098815.3 NP_001092285.1 protein TESPA1 isoform 1
NM_001136030.3 NP_001129502.1 protein TESPA1 isoform 1
NM_001261844.1 NP_001248773.1 protein TESPA1 isoform 2
NM_001351148.1 NP_001338077.1 protein TESPA1 isoform 2
NM_001351149.2 NP_001338078.1 protein TESPA1 isoform 1
NM_001351150.1 NP_001338079.1 protein TESPA1 isoform 3
NM_001351151.1 NP_001338080.1 protein TESPA1 isoform 4
NM_001351152.1 NP_001338081.1 protein TESPA1 isoform 4
NM_001351153.1 NP_001338082.1 protein TESPA1 isoform 4
NM_001351154.1 NP_001338083.1 protein TESPA1 isoform 4
NM_001351155.1 NP_001338084.1 protein TESPA1 isoform 4
NM_014796.2 NP_055611.1 protein TESPA1 isoform 2
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
22561606 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TESPA1 Protein Structure

KRAP_IP3R_bind

KRAP_IP3R_bind: Ki-ras-induced actin-interacting protein-IP3R-interacting domain (126 - 287)

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  • 521 a.a.
Protein Preferred Names Protein Names

protein TESPA1

thymocyte-expressed positive selection-associated protein 1

Related Diseases

Diseases Alias
Pancreatic Squamous Cell Carcinoma
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14383 TESPA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TESPA1 VGNC VGNC:35756
Canis familiaris TESPA1 VGNC VGNC:47259
Mus musculus TESPA1 MGD MGI:1914846
Felis catus TESPA1 VGNC VGNC:66091
Macaca mulatta TESPA1 VGNC VGNC:79775